To Evaluate the Efficiency of Dexmedetomidine in Atomized Intranasal form for Sedation in Minor Oral Surgical Procedures

Aim: This study aims to evaluate the efficiency of dexmedetomidine in atomized intranasal form for sedation in minor oral surgical procedures.

Materials and Methods: A total 25 patients fitting the inclusion and exclusion criteria were selected from the outpatient Department of Oral

and Maxillofacial Surgery, Saraswati Dental College and Hospital, Lucknow. The drug was administered intranasally half an hour before the

surgical procedure. The volume of drug used was recorded. The readings of all the parameters of sedation began 30 min after the drug had been

administered. Intranasal sedation status was assessed by Ramsay sedation score and observer’s assessment of alertness/sedation scales, every

15 min throughout the procedure. Results: The primary outcome variable in this study is depth of sedation produced by intranasally administered

dexmedetomidine. Secondary variables included respiratory rate, blood pressure (BP), heart rate (HR), and oxygen saturation (SpO2). The

statistical software used was SPSS 20.0 for Windows (SPSS, Chicago, IL, USA). Data were expressed as mean and standard deviation or

number (percentages). Sedation and behavior scores were analyzed by proportions. Hemodynamic variables including HR, SpO2, and BP

and respiratory rate were analyzed by repeated measures ANOVA. When a significant result was obtained, the Tukey test was applied for

post hoc pairwise comparisons. P < 0.05 was considered as statistically significant. All the parameters were recorded at a set interval of time.

Conclusion: In conclusion, intranasal administration of 1.5 mg/kg atomized dexmedetomidine was clinically effective, convenient, and safe

for the sedation of patients undergoing minor oral surgical procedures.

Keywords: Atomizer, dexmedetomidine, intranasal sedation

Sadaf Syed, Tajamul Hakim, Mohd Rameez Riyaz, Ravinder Singh Bedi