1. As Oral Medicament: Two main reasons:
• In the treatment of abscess where periapical tissue is involved.
• To limit swelling, as well as metastasis of infection to vital organs.
2. Endodontic regenerative procedure: the regenerative procedure is an alternate clinical approach for apexification.
3. Intracanal medicament: When freshly mixed metronidazole cream was applied for 1 week, it has a success rate of 85% after 24 months.
4. Obturating material: Metronidazole used as obturating material along with two other antibiotic drugs used in (LSTR) therapy & (NIET) treatment.
• Alternative method, when conventional endodontic therapy is not possible OR
• If teeth show the presence of external h internal resorption.
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